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Bioinformatics Shared Resources

Sanford Burnham Prebys Medical Discovery Institute


T-COFFEE


Multiple sequence alignment program for both protein and DNA.

This multiple sequence alignment program is more sophisticated and well regarded than those in most DNA/Protein toolboxes such as DNAStar, GCG, etc. However, it runs in the command line mode on linux systems. It can however handle very large/long alignments and more extensive searches for the best possible alignment.

Category
Multiple Sequence Alignment
Where? How?
T-Coffee is maintained on the emu linux server. It can be run by typing "t_coffee" from any directory.
Last installation and version
The latest installed version is v 2.66 installed on May 27, 2005.
Prior installations available

Documentation
programs web site
License
GPL (GNU public license)
Local expertise
IT: Martin Fleming

NOTE WELL
The program often outputs (depending on settings) an intermediate phylogeny used in making progressively better alignments - not the final phylogeny as a result of the alignment.

Technical Data

  • tested on:
  • emu path: /usr/local/share/t_coffee_2.66/
  • on $PATH? yes​